The Missouri Great River Road is a fantastic drive. From the humble beginnings of Mark Twain in Hannibal to the soaring majesty of the St. Louis Arch, the Missouri Great River Road spans a broad range of American culture. Variety is what you’ll find as you travel this scenic stretch of the Mississippi River. Take in the rich city life of St. Louis, home to some of the top restaurants in the Midwest. Sample the brews at the Anheuser-Busch Brewery, home of some of America’s favorite beers. Discover the rich French heritage of places like Ste. Genevieve. See where the Missouri River meets the Mississippi River at St. Charles. See the historic sites in Cape Girardeau and visit the Cape Girardeau Conservation Nature Center to learn about the natural history of the river and the area. Learn about the earthquakes that rocked southern Missouri in 1811 and 1812 at the New Madrid Historical Museum. There’s a lot to see and do as you travel along the Missouri Great River Road.